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Association Between Vitamin D Status, Oxidative Stress Biomarkers And Viral Load In Human Immunodeficiency Virus Type 1 Infection.
CONCLUSION: These results suggest the bimodal influence of vitamin D in the modulation of immune response in HIV-1 infection, considering its differential susceptibility to modulation of the various immune targets and pathways.
PMID: 28990534 [PubMed - as supplied by publisher]
Source: Current HIV Research - October 5, 2017 Category: Infectious Diseases Authors: Flauzino T, Simão AN, de Almeida ER, Morimoto HK, Oliveira SR, Alfieri DF, Ueda LT, Dichi I, Reiche EM Tags: Curr HIV Res Source Type: research
Tobacco and Antiretrovirals Modulate Transporter, Metabolic Enzyme, and Antioxidant Enzyme Expression and Function in Polarized Macrophages.
CONCLUSION: This data suggest a mechanism by which tobacco use impairs HIV antiretroviral therapy to increase intracellular drug concentrations in this important cellular reservoir.
PMID: 30706821 [PubMed - as supplied by publisher]
Source: Current HIV Research - January 29, 2019 Category: Infectious Diseases Authors: Mu Y, Patters BJ, Midde NM, He H, Kumar S, Cory TJ Tags: Curr HIV Res Source Type: research
Camu Camu effects on microbial translocation and systemic immune activation in ART-treated people living with HIV: protocol of the single-arm non-randomised Camu Camu prebiotic pilot study (CIHR/CTN PT032)
Introduction
Despite the success of antiretroviral therapy (ART) in transforming HIV disease into a chronic infection, people living with HIV (PLWH) remain at risk for various non-AIDS inflammatory comorbidities. Risk of non-AIDS comorbidities is associated with gut dysbiosis, epithelial gut damage and subsequent microbial translocation, and increased activation of both circulating CD4+ and CD8+ T-cells. Therefore, in addition to ART, novel gut microbiota-modulating therapies could aid in reducing inflammation and immune activation, gut damage, and microbial translocation. Among various gut-modulation strategies under inve...
Source: BMJ Open - January 17, 2022 Category: General Medicine Authors: Isnard, S., Fombuena, B., Ouyang, J., Royston, L., Lin, J., Bu, S., Sheehan, N., Lakatos, P. L., Bessissow, T., Chomont, N., Klein, M., Lebouche, B., Costiniuk, C. T., Routy, B., Marette, A., Routy, J.-P., For the Camu Camu Study Group Tags: Open access HIV/AIDS Source Type: research
The Effect of curcumin on Expression of INF γ, TNF-α and iNOS Genes in PBMCs Infected with Leishmania major MRHO/IR/75/ER
CONCLUSIONS: These findings suggest the potential of curcumin against Leishmaniasis Keywords: Curcumin, Gene expression, Leishmania major, PBMCs, Tumor necrosis factor,Interferon gamma.PMID:35379161 | DOI:10.2174/1871526522666220404083220
Source: Infectious Disorders Drug Targets - April 5, 2022 Category: Infectious Diseases Authors: Soheila Alinejad Shahram Khademvatan Shahla Amani Negar Asadi Khosrow Hazrati Tappeh Elham Yousefi Touraj Miandoabi Source Type: research
Capparis spinosa inhibits Leishmania major growth through nitric oxide production in vitro and arginase inhibition in silico
This study aimed to evaluate the effect of C. spinosa' extracts on Leishmania major promastigotes and amastigotes growth as well as on L-arginine metabolic pathways, especially the production of leishmanicidal molecules such as nitric oxide. Our results showed that C. spinosa' methanolic and aqueous extracts contained polyphenols and flavonoids at different concentrations. The methanolic extract of C. spinosa, compared to the aqueous extract, showed significantly higher amounts of total polyphenols (21.23 ± 1.08) mg GAE/g of dw (P < 0.05), as well as a higher antioxidant activity evaluated respectively by Reducing Powe...
Source: Experimental Parasitology - December 29, 2022 Category: Parasitology Authors: Dounia Darif Imane Nait Irahal Ikram Hammi Ayyoub Kihel Mohamed Reda Kachmar Myriam Riyad Fouzia Hmimid Khadija Akarid Source Type: research
IJERPH, Vol. 15, Pages 1037: Clinical Efficacy Associated with Enhanced Antioxidant Enzyme Activities of Silver Nanoparticles Biosynthesized Using Moringa oleifera Leaf Extract, Against Cutaneous Leishmaniasis in a Murine Model of Leishmania major
In conclusion, treatment with silver nanoparticles biosynthesized using Moringa oleifera extract has higher and faster clinical efficacy than standard pentavalent antimonial treatment, probably by boosting the endogenous antioxidant activity.
Source: International Journal of Environmental Research and Public Health - May 22, 2018 Category: Environmental Health Authors: Manal El-khadragy Ebtesam M. Alolayan Dina M. Metwally Mohamed F. Serag El-Din Sara S. Alobud Nour I. Alsultan Sarah S. Alsaif Manal A. Awad Ahmed E. Abdel Moneim Tags: Article Source Type: research
Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis
This study aimed to investigate the flavonoid quercetin’s therapeutic potential in L. (V.) braziliensis infection. Quercetin showed antiamastigote (IC50 of 21 ± 2.5 µM) and antipromastigote (25 ± 0.7 µM) activities and a selectivity index of 22. The treatment of uninfected or L. (V.) braziliensis–infected macrophages with quercetin increased reactive oxygen species (ROS)/H202 generation without altering Nitric Oxide (NO) production. Oral treatment with quercetin of infected hamsters, starting at 1 week of infection for 8 weeks, reduced the lesion thickness (p > 0.01) and parasite load (p > 0.001). The results...
Source: Frontiers in cellular and infection microbiology - January 13, 2023 Category: Microbiology Source Type: research
Selenium and Zinc supplementation in HIV-infected patients
Conclusion: In the present study, we identified some clinical evidence of a potential beneficial effect of selenium supplementation in HIV-infected patients.PMID:36728996 | DOI:10.1024/0300-9831/a000778
Source: Cell Research - February 2, 2023 Category: Cytology Authors: Samira Pourmoradian Leila Rezazadeh Helda Tutunchi Alireza Ostadrahimi Source Type: research
Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
Neglected Tropical Diseases include a broad range of pathogens, hosts, and vectors, which represent evolving complex systems. Leishmaniasis, caused by different Leishmania species and transmitted to humans by sandflies, are among such diseases. Leishmania and other Trypanosomatidae display some peculiar features, which make them a complex system to study. Leishmaniasis chemotherapy is limited due to high toxicity of available drugs, long-term treatment protocols, and occurrence of drug resistant parasite strains. Systems biology studies the interactions and behavior of complex biological processes and may improve knowledge...
Source: Frontiers in cellular and infection microbiology - April 30, 2021 Category: Microbiology Source Type: research
The photodynamic action of pheophorbide a induces cell death through oxidative stress in Leishmania amazonensis
Publication date: Available online 11 August 2017 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): Nathielle Miranda, Hélito Volpato, Jean Henrique da Silva Rodrigues, Wilker Caetano, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Celso Vataru Nakamura Leishmaniasis is a disease caused by hemoflagellate protozoa, affecting millions of people worldwide. The difficulties of treating patients with this parasitosis include the limited efficacy and many side effects of the currently available drugs. Therefore, the search for new compounds with leishmanicidal action is necessary. Photodynamic therapy has...
Source: Journal of Photochemistry and Photobiology B: Biology - August 11, 2017 Category: Speech-Language Pathology Source Type: research
Selenium and Zinc supplementation in HIV-infected patients
Conclusion: In the present study, we identified some clinical evidence of a potential beneficial effect of selenium supplementation in HIV-infected patients.PMID:36728996 | DOI:10.1024/0300-9831/a000778
Source: International Journal for Vitamin and Nutrition Research - February 2, 2023 Category: Nutrition Authors: Samira Pourmoradian Leila Rezazadeh Helda Tutunchi Alireza Ostadrahimi Source Type: research
